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Antidiabetogenic effect of glucagon-like peptide-1 (736)amide in normal subjects and patients with diabetes mellitus

After 10 min of administration, the total radioactivity concentration increased significantly in all tissues, with the mean renal tissue concentration reaching 223 ng (Eq

Pyridinic nitrogen (N-6) and pyrrolic nitrogen (N-5) provided lone pair electrons as Zn 2+ adsorption sites, inducing surface redox reactions

When these affinity-enhancing mutations were added to full-length rat amylin, all three mutated rat amylin analogs showed enhanced potency for amylin receptor 1/2 activation by 5- to 10-fold compared to endogenous rat amylin and a clinical drug pramlintide (Figure 9A, 9B and Table 3)

The original 2015 Cell Metabolism study demonstrated that intraperitoneal MOTS-c injections (5 mg/kg) in mice fed a high-fat diet prevented obesity and insulin resistance, with effects on fat mass, fasting glucose, and insulin sensitivity that rivaled pharmaceutical intervention [1]