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The medium was then replaced by fresh medium supplemented with either 2 mM U- 13 C-Glutamine or 0.2 mM 13 C 2 -Cystine for the indicated time

Patients with systemic IGF-1 deficiencythose with growth hormone insensitivity (Laron syndrome) or adult GH deficiencyexhibit thin, sparse, slow-growing hair that responds poorly to conventional treatments