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Because retatrutide is administered as a once-weekly subcutaneous injection, its long pharmacokinetic half-life estimated at approximately six days in the Phase 2 trial data means that plasma concentrations remain relatively stable throughout the week

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a further aspect of the invention pertains to treating obesity or related chronic metabolic condition by administering a therapeutically effective amount of one or more cations chosen from Tables 3a and 3b followed by the administration of one or more cations of the invention

Gpr75-deficient mice are protected from high-fat diet-induced obesity