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Research has used MT-1 to characterise these melanin-independent photoprotection mechanisms and establishing that MC1R activation provides a layer of cellular UV protection through DNA repair enhancement and oxidative stress reduction thats distinct from and additive to the physical UV-screening function of melanin pigmentation

Several studies which focus on blood biochemical markers, gut microbiota, and fecal SCFAs, uncover a close association between gut microbiota and the progression of MASLD, thereby improving its clinical diagnosis (142144)

Using a transgenic reporter strain that carries GFP fused to a peroxisome import signal 79,80 , we found that MUFA accumulation due to ash-2 depletion, fat-2 depletion or oleic acid supplementation led to increased intensity of the GFP signal in the intestine, indicative of increased number/function of peroxisomes in this fat storage tissue (Fig