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It is quite possible that your GP will have not heard of EDS before, or knows little about it

Acknowledgements This work was supported in part by a grant from the National Research Foundation of Korea (NRF-2020R1A2C201215513 to Y.H.), Republic of Korea

Keep in mind that supplements are an ancillary under optimal conditions

Importantly, they also illustrate how defects at distinct levels of the UPS, substrate recognition, ubiquitin recycling or proteasome targeting, can converge on a common outcome of proteotoxic stress and neurodegeneration