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Protein synthesis declines with age, and men lose roughly 12 kg (27%) and women 5 kg (15%) of lean body mass from ages 25 to 70, as measured by potassium-40 counting

doi: 10.1152/ajplung.1998.275.4.L818

[38 ]It is clear from these data that the effects of the retinoids as sole therapeutic agents are limited, perhaps mainly to hematologic malignancies, which tend to develop RA resistance over time

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