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Through this mechanism, ITCs bolster cellular defenses against oxidative damage and help eliminate carcinogens

461,462,463,464 Notably, recent studies further support the pivotal role of NRF2 in intracellular metabolic reprogramming during hepatocyte proliferation, demonstrating its involvement in promoting glycolysis, nucleic acid synthesis, the oxidative pentose phosphate pathway (PPP), and NAD + /NADH synthesis, while downregulating OXPHOS

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Long-standing GERD with significant esophageal damage may require longer treatment periods and show slower response compared to milder, more recent-onset reflux