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Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, Perez JL , et al

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It was then that I began not only overeating at mealtimes, but I would also binge and hide food from my parents

This interaction appears to initiate a series of intracellular signaling cascades

The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default