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The underlying mechanism is primarily associated with inhibiting macrophage Mincle-mediated necroptosis and the inflammatory response directed towards tubular epithelial cells

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

The addition of citrulline has not significantly altered incidence or severity, but formal head-to-head trials are absent, emphasizing the need for vigilant post-marketing reporting

10.1681/ASN.2010070705 90 KlapanK.SimonD.KaraulovA.GomzikovaM.RizvanovA.YousefiS.et al (2022)

Finally, elution buffers are added to disrupt the binding interaction, and release the target molecule, then collected in purified form