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10.1016/j.bbadis.2021.166287 51 FrazerD

Treatment of T cells with the GLS inhibitor 6-diazo-5-oxo-L-norleucine (DON) resulted in a significant decrease in the percentage of IL-17A + Th cells and led to a reduction in IL-17A expression in T cells by more than half (50)

Taken together, these studies converge on the conclusion that naringenin exerts multifaceted modulation of the cholinergic system through inhibition of AChE and BuChE, upregulation of acetylcholine levels, and protection of neural substrates