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160 MelisV.ZabkeC.StamerK.MagbagbeoluM.SchwabK.MarschallP.et al (2015)

Natural proteolysis of inactive human TyrRS generates two fragments with distinct cytokine activities and C terminally appended EMAP II-like domain is shown to regulate its cell signaling function [67, 68]

3.3 Genetic mutations associated with Mn dyshomeostasis Mutations in transporters of Mn can disrupt Mn homeostasis, leading to either deficiency or overload

(3) emerging intervention strategies targeting mitochondrial metabolism, including small-molecule inhibitors, combination therapies, and translational opportunities