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All studies written in preclinical and clinical language that highlighted the anticancer molecular mechanisms, signaling pathways and action targets of bromelain were included

Beyond classical applications in neurodegeneration, neuroinflammation, and tumor biology, HMC3-based platforms are increasingly relevant to studies of systemic and organ-brain interactions, including the gutbrain axis (351353), metabolic disorders (241), immune-endocrine cross-talk, and reproductive system pathologies (250), where microglia contribute to neuroendocrine regulation and reproductive axis remodeling

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However, most of the population, particularly in third-world nations, cannot afford the long-term use of these drugs