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Subcutaneous dosing of female rats from before mating through gestation and lactation and allowed to deliver caused maternal dystocia and periparturient mortality, increases in stillbirths and neonatal deaths, and reduced pup body weight starting at doses equivalent to 0.1 times the human 5 mg intravenous dose (based on AUC) (see Data)

TB-500's pharmacokinetics reflect its actin-binding behavior

We hypothesize that Omicron infections occurred against a background of mRNA-induced persistent spike protein, inflammatory lipid nanoparticles, and residual process-derived DNA, creating a toxic synergistic environment