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History of scurvy and use of vitamin C in critical illness: A narrative review

Peptides with sequences rich in hydrophobic residues, or those with a high proportion of basic amino acids (lysine, arginine, histidine) that require protonation for charge-mediated aqueous solubilisation, typically reconstitute cleanly and completely in 0.1% acetic acid water whereas the same peptides may form aggregates, gels, or turbid suspensions when reconstitution with neutral sterile water or bacteriostatic water is attempted first

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10.1016/j.pcad.2023.10.003 140 OklaM.KimJ.KoehlerK.ChungS