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In skeletal muscle, AKT phosphorylation activates mTORC1, increasing ribosomal protein S6 kinase activity and protein translational efficiency the primary molecular mechanism underlying the hypertrophic stimulus

Psychoneuroendocrinology (2021) 129:105243

However, the evidence for meaningful clinical benefit in elderly populations remains preliminary, and the risk-benefit calculation must account for potential effects on glucose metabolism and cancer risk