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Furthermore, recent findings reveal that alterations in BBB and its transporters affect the entry of therapeutic drugs designed to treat neurodegenerative diseases (Carvey et al., 2009)

43,44 In specific, MAPK (mitogen-activated protein kinase) signaling, JAK-STAT, and NF-B (nuclear factor kappa-B) pathway have been implicated in mediating the favorable effects of SPMs in cardiometabolic disorders, 45,46 whereas the anti-inflammatory effects of synthetic SPMs are in marked contrast to their low picograms per milliliter concentrations reported in humans

(PubMed) Hathcock JN, Shao A

J Pharmacol Sci 95:1926 Petrovic I, Dobric I, Drvis P, Shejbal D, Brcic L, Boban Blagaic A et al (2006) An experimental model of prolonged esophagitis with sphincter failure in rat and therapeutic potential of gastric pentadecapeptide BPC 157