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Carbachol (Figure 7) is a synthetic cholinergic agent with greater potency relative to pilocarpine

Plant Physiology 148, 10551067

Additionally, copper can selectively regulate the binding of HIF-1 to affected gene promoters, thereby affecting its transcriptional activity (102)

The vasorelaxant action of OS extract was reduced via L-NAME, indicating that the NO/cGMP pathway is implicated in the vasorelaxant mechanism of this herb