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Given that neurodegenerative diseases predominantly affect middle-aged and elderly populations, cellular senescence has been increasingly recognized as a central driver of disease onset and progression

Cytokines, after binding to their receptors, lead to activation of PKC and MAPK that further corresponds to the development of neuropathic pain (61)

11 (39), e2308900

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However, in 2021, the AEMPS ordered the withdrawal of the food supplement "Melatonin 3 mg capsules" because that dose confers the status of medication, but without having been evaluated or authorized, hence it could be a risk to the health of patients [82]