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Exp Gerontol 36:209220 Kiray M, Ergur BU, Bagriyanik A, Pekcetin C, Aksu I, Buldan Z (2007) Suppression of apoptosis and oxidative stress by deprenyl and estradiol in aged rat liver

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564 HO-1 and GPX4 were downregulated due to Nrf2 defects in astrocytes, leading to increased mitochondrial fragmentation, DNA oxidation, and lipid peroxidation in mouse astrocytes, 564 suggesting that Nrf2 deficiency promotes ferroptosis in astrocytes in AD mice

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In a differential alkylation approach, peptides containing Cys (either chemically alkylated or initially oxidized) are used to estimate Cys oxidation levels, while peptides not containing Cys are used for measurement of protein expression