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From these metrics, participants were stratified into four clinical groups: neuropathological AD diagnosis with dementia (dementia, 25 participants), neuropathological AD diagnosis without dementia (resilient, 25 participants), no AD or other neurological disease diagnosis with dementia (frail, 26 participants), and a control group with no AD or other neurological disease diagnosis and negligible cognitive decline at time of death (control, 26 participants)

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Such dynamic changes in putative biomarkers is a well-established aspect of schizophrenia (Figure 2 where this scenario is described as Adaptive GSH Changes. Figure 2 (B) In this model, GSH changes are considered to be adaptive consequences of glutamatergic aberrations