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Articles published before August 2018 in the aforementioned databases were included

Current Western medical treatment is based on disease-modifying anti-rheumatic drugs (DMARDs) (4), but there are problems such as insufficient efficacy, drug resistance and adverse reactions, and the clinical outcomes of RA patients are not satisfactory (3)

10.1016/j.lfs.2017.07.026 230 ZavodnikI.BukoV.LukivskayaO.LapshinaE.IlyichT.BelonovskayaE.et al (2019)

You can review their full data in a peer-reviewed paper on Semax gene expression changes in rat brain ischemia documenting how the peptide affects immune and vascular system pathways relevant to cognitive recovery

Additionally, astaxanthin has been shown to enhance skin moisture content and reduce transepidermal water loss (TEWL), addressing another critical aspect of skin agingdehydration