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Activation of p53 prevents APAP-induced toxicity in vitro by promoting Nrf2 activation and its downstream target gene expression To further elucidate the protective mechanism of p53 against APAP toxicity, we treated AML12 cells with Dox (125500 nM) and also found a dose-dependent upregulation of mRNA levels of Mrp2/3/4, Nqo1 , and GST/ (Fig

Ovarian endometriomas per se impair ovarian reserve, as evidenced by decreased serum anti-Mllerian hormone (AMH) levels, reduced antral follicle count (AFC), and histopathological findings of decreased follicular density and vascular abnormalities in the ovarian cortex surrounding these cysts, with up to 16% of cases exhibiting complete absence of follicles

Many factors contribute to aging, including the accumulation of macromolecular damage in response to a variety of environmental and endogenous stressors

Morphologically, it is mainly characterized by mitochondrial atrophy, increased membrane density and decreased or absent mitochondrial cristae

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