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The mechanism of NAC-mediated Notch2 reduction was elucidated by promoting Notch2 degradation through Itch-dependent lysosome pathway

Secondary hyperuricemia is also seen in individuals with myeloproliferative disorders undergoing therapy where there is excess cellular turnover (cell lysis leads to an accumulation of nucleotides) or in cases of Von Gierke disease or fructose intolerance, which increases substrate for PRPP synthesis

ClinicalTrials.gov was queried to identify registered or ongoing trials

doi: 10.1172/JCI178722 2 MengXLayhadiJAKeaneSTCartwrightNJKDurhamSRShamjiMH

PQQ, a vitamin-like compound found in fruits and vegetables, is a powerful antioxidant that protects nerve cells, supports the mitochondria, enhances memory, and lowers inflammation