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We speculate that PUFAs and iron are specifically absorbed in the small intestine 32,33,44 , which could be one explanation for small intestinal disease localization and a requirement for GPX4 activity in the small intestine

Br J Pharmacol (2006) 147(7):7909.10.1038/sj.bjp.0706672 70 XiaoDMPakJHWangXSatoTHuangFLChenHCet alPhosphorylation of HMG-I by protein kinase C attenuates its binding affinity to the promoter regions of protein kinase C and neurogranin/RC3 genes