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These inhibitors block FIN56- or erastin-induced GPX4 degradation to prevent ferroptosis (107,108)

While challenging the importance of the protein binding hypothesis, it was instead suggested that the key mechanism of cell death involves P450-derived ROS formation during APAP metabolism, which triggers extensive LPO [59, 60]

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Awareness of liver disease was assessed based on a positive response to ever told you had any liver condition on the Medical Conditions Questionnaire