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We propose that restoring cellular voltage, reducing tissue hypoxia, and mechanically forcing detoxification pathways is the essential prerequisite for biochemical interventions to be effective

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Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA

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Emphasis should be placed on clarifying the regulatory pathways of immune-metabolic axes mediated by dual-regulating molecules through hub molecules such as mTOR and HIF-1, and expanding mechanistic exploration in emerging fields such as the gut-lung axis and neuro-immune-metabolic crosstalk (Harbaum et al., 2021