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Blood 140:152156 Zerbit J, Detroit M, Meyer A, Decroocq J, Deau-Fischer B, Deschamps P, Birsen R, Mondesir J, Franchi P, Miekoutima E (2022) Patients with hematological malignancies treated with T-cell or B-cell immunotherapy remain at high risk of severe forms of COVID-19 in the omicron era

Abnormal trajectory: expanding redness beyond 3cm diameter, increasing warmth, new onset of pain after initial comfort, or lymphatic streaking (red lines extending from the site toward the trunk)

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The COVID-19 pandemic, as highlighted by various epidemiological studies, exacerbated the global gap in PN management

The importance of Cat in the neoplastic scenarios has long been appreciated, as various studies have demonstrated that increased activity of this enzyme in tumour cells constitute a protection mechanism against cell death induced by reactive oxygen species (ROS), and that by inhibiting this enzyme, the neoplastic cells become once more vulnerable to this outcome [54], [55]