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Native Americans were chewing on the bark of the white willow for pain relief and fever reduction long before the barks salicin led to the invention (and, later, FDA approval) of aspirin

Curcumin-induced degradation of PKC is associated with enhanced dentate NCAM PSA expression and spatial learning in adult and aged Wistar rats

2012;131:E5665

Its short peptide structure allows researchers to work with clearly defined molecular compositions, improving experimental reproducibility and analytical accuracy

That convergence of independent findings across diverse research groups adds weight to the overall body of evidence in a way that designed peptides with narrower mechanistic rationales cannot replicate