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Applications include investigating stroke recovery mechanisms, neurodegenerative disease prevention, and ocular health optimization

a NNMT inhibitor such as a cation of Formula I or IA, or otherwise disclosed herein chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increases intracellular NAD+ levels to provide muscular therapy

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Taking a vitamin B complex is recommended because there is evidence that a combination of neurotropic B vitamins is more effective than taking a single vitamin B supplement, due to the synergies between the different vitamins.