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In RA patients, there are no associations between vitamin B6 intake and plasma PLP, no indication of congenital defects of vitamin B6 metabolism (34, 36, 168) and no vitamin B6 deficiency as judged by other B6 markers, like erythrocyte aspartate transaminase activity coefficient (EAST-AC) (191), erythrocyte PLP (36) or urinary PA excretion (36)

doi: 10.5173/ceju.2013.01.art19

Moreover, theranostic liposomes, which co-deliver drugs and imaging agents, have been developed to enable simultaneous therapy and real-time monitoring [121]

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Additional studies have demonstrated that the biologicals effects of thalidomide and IMiDs result from their binding to cereblon, which culminates in the ubiquitination and degradation of neo-substrates 47