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IV administration also makes magnesium far more practical at therapeutic doses: oral magnesium at comparable concentrations commonly causes diarrhea before it reaches circulation

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PMID: 33234378 PLoS Biol The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b