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In addition, the prodrugs must have structural features for effective translocation across the cellular membrane via the targeted transporter, as, otherwise, they would act more as inhibitors than substrates (77)

[DOI] [PubMed] [Google Scholar] 121.Grard C., Bruyns C., Marchant A., Abramowicz D., Vandenabeele P., Delvaux A., Fiers W., Goldman M., Velu T

10.1016/0167-4838(95)00141-G Biochim

So they use it for three months, six months, up to a year