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Shikonin (SHI) is a naphthoquinone compound extracted from the root of Lithospermum erythrorhizon Siebold and Zucc, which has been widely used in Asia, and is currently believed to have less obvious side effects, and has anti-tumor (Wang et al., 2024), anti-viral (Watson et al., 2023) effects

Therefore, the observed cross-talk between the AR and EGFR axes leads to the assumption that EGFR-induced EMT and androgen-independence could occur simultaneously in prostatic tumor cells [26]

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These findings suggest that WD repeat-mediated protein interactions of WDR11 are key requirements for normal puberty 45,48 , corresponding to our findings in young people aged 1525 years

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