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For peripheral vascular disease, where reduced blood flow to the extremities causes pain and tissue damage, this collateral activation mechanism could theoretically provide meaningful benefit

G., Lamarca, A., Rodrigues, P

This approach could delay tumor recurrence and progression [23]

However, using a monoclonal rat anti-mouse and rabbit anti-human antibody to stain for CD31, increased expression of mouse CD31 on endothelial cells lining the vessel walls in the PDX tumor tissue was observed compared to the primary tumor, suggesting a switch of human to mouse vessels