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Evid Based Complement Alternat Med 2021 Bellinger FP, Bellinger MT, Seale LA, Takemoto AS, Raman AV, Miki T et al (2011) Glutathione peroxidase 4 is associated with neuromelanin in substantia nigra and dystrophic axons in putamen of Parkinsons brain

10.3892/mmr.2020.11376 207 TanS.SagaraY.LiuY.MaherP.SchubertD

[4] Oxidative stress is linked to various neurological disorders in both horses and humans

Regulatory frameworks must evolve in tandem, embracing flexible, data-driven approaches that account for the complexity and subtlety of neuroprotective interventions

Together, these data demonstrate that oxidative stress-induced exaggerated glutathione oxidation mitigates mis-paired disulfide bond reduction causing BisAb aggregation intracellularly