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Science 371 (6524), eabb0738

Corneal ulcers have to stop getting worse before they can start getting better

Together, they explore the often-overlooked connections between hormone imbalances, nutrient deficiencies, thyroid dysfunction, autoimmune disease, and metabolic stressors like insulin resistance

The SCFA mixture trials (butyrate 40 mM + propionate 30 mM + acetate 60 mM) have shown more consistent positive results in radiation proctitis than butyrate-only trials

Zinc also promotes assembly of the vacuolar H-ATPase on endolysosomal membranes, lowering luminal pH to enable ligandreceptor dissociation, enzyme activation and endosome maturation