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The positive signal was detected using the 1-Step Ultra TMB-ELISA substrate (Thermo Scientific)

The study found that C-X-C motif chemokine ligand 10 (CXCL10) and its receptor CXCR3 play key roles in regulating the infiltration of CD8+ T cells into the brain, and the infiltrated CD8+ T cells appear to interact with microglia to jointly promote ADs neurodegeneration