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Growth hormone deficiency in children is defined by the Pediatric Endocrine Society as peak GH below 10 ng/mL on two separate stimulation tests, combined with a subnormal growth velocity for age and sex

Additionally, the expression of core photoaging drivers MMP-1/3 is suppressed through dual mechanisms: antagonizing AP-1 transcriptional activity and interfering with NF-B signaling (Lee et al., 2012