glutathione transferase pathway

glutathione transferase pathway The role of glutathione-S-transferase in anti-cancer drug resistance Glutathione metabolic pathways. GCL, glutamate

Name: glutathione transferase pathway The role of glutathione-S-transferase in anti-cancer drug resistance Glutathione metabolic pathways. GCL, glutamate
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SKU: 52865774166
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Glutathione metabolic pathways. GCL, glutamate cysteine ligase; GST, Download Scientific Diagram Frontiers Glutathione S Transferase Enzymes in Plant Pathogen Interactions The role of glutathione S transferases in human disease pathogenesis and their current inhibitors ScienceDirect Frontiers Glutathione S Transferases: Role in Combating Abiotic Stresses Including Arsenic Detoxification in Plants Glutathione Dependent Pathways in Cancer Cells

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Description

Gln depletion therapy can inhibit Gln metabolism in tumor cells, but in colon cancer, it has been observed that Gln depletion promotes the expression of the aspartate/glutamate transporter SLC1A3 in tumor cells, increasing the intracellular glutamate concentration and promotes Gln synthesis

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122,123,124 Gln enters the cell via the amino acid transporter ASCT2/SLC1A5 and is converted to glutamate in the mitochondria by a deamination reaction involving glutaminase (GLS)