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11 , 15 , 27 It is well known that seminal OS induces LPO of the sperm cell membrane, sperm DNA fragmentation (SDF) and, consequently, apoptosis

Notably, pharmacological inhibition of the PI3K-AKT-mTOR pathway reverses Sunitinib- and Sorafenib-resistant phenotypes driven by aberrant AKT activation, underscoring that this pathway represents a potential therapeutic node to overcome drug resistance (267, 272)

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