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Nat Immunol (2017) 18:48898

[DOI] [PMC free article] [PubMed] [Google Scholar] 734

169.Savage, M

Lower levels might result in compromised detoxification, leading to an increased toxic load in the body

These comprise both hepatic and extrahepatic conditions, including portal hypertension in cystic fibrosis, porto-sinusoidal vascular disease, malignant mesothelioma, incident type 2 diabetes (T2D), cardiovascular disease risk, metabolic syndrome, fibrosing NAFLD, chronic kidney disease (CKD), neurodegenerative disorders and dementia, idiopathic pulmonary arterial hypertension, and Corona Virus Disease 2019 (COVID-19)