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Next, we used a targeted LC-MS metabolomics assay to confirm these trends in one additional sensitive cell line (U87) and one additional resistant cell line (A172)

Gene expression of claudin-5 and occludin, which are the highest prevalent transmembrane tight junction proteins in the BBB, were reduced as consequence of MGO treatment [53, 57]

We delve into their biological functions and examine their roles across various cancer types

ATP (adenosine triphosphate) acts as a co-substrate for both enzymes (Figures 2, 3)

[7] [9] These contraindications are based on known metabolic pathways, clinical case reports, and established pharmacological principles, and are supported by clinical guidelines and expert consensus