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the resulting ester group may then be hydrolyzed and converted into acyl azide with DPPA, followed by Curtius rearrangement with an alcohol, such as tert-butanol, to provide the corresponding N-Boc protected substrate (not depicted)

Regular testing for nutrient levels can help identify any deficiencies early on

Symptoms of B12 deficiency can include fatigue, weakness, pale skin, shortness of breath, dizziness, memory problems, mood changes, and tingling or numbness in the hands and feet

Effect of hormonal contraceptives on vitamin B12 level and association of the latter with bone mineral density