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Notably, SHMT1 and SHMT2 (SHMT2 is a splice variant of SHMT2) function as scaffolding proteins during DNA replication to exert their regulatory effects, and are localized in the cell nucleus during the S phase along with TYMS and DHFR as part of the thymidine cycle

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Associated datasets are provided in Supplementary Tables 14 and 67

In neurodegenerative contexts, a critical dichotomy emerges: a loss of support function contrasts with reactive, potentially inflammatory metabolic reprogramming

When the body rebuilds its own glutathione capacity, thats when the nervous system, mitochondria, and immune system start working with you again instead of against you