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doi: 10.14218/Jcth.2021.00428 144 PimpinL.Cortez-PintoH.NegroF.CorbouldE.LazarusJ

However, restoration of circulation is accompanied with inevitable cell death, oxidative stress damage, inflammation and programmed cell death, and eventually results in tissue injury such as myocardial infarction (MI) [80]

SOD1 is an important protein involved in oxidative stress, while Nrf2 participates in antioxidant responses [32]

Autoimmune diseases are caused by an inappropriate immune response against self antigens, resulting in local tissue-specific and systemic chronic cascades of inflammation and tissue damage