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Functionally, glutathione was essential for melatonin-mediated immunosuppression, as IKE co-treatment abolished the reductions in IL-5, IL-13, and IL-4 production observed with melatonin alone ( Figures 8FH )

Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro-/anti-inflammatory cytokine network, protection against oxidative damage and anti-apoptotic effects