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3 Mechanisms of drug resistance driven by tumor heterogeneity Tumor heterogeneity enables therapeutic resistance through interconnected genetic, epigenetic, phenotypic, and microenvironmental mechanisms that coexist within tumors and interact, as summarized in Table 1 and Figure 1 , to generate drug-tolerant subpopulations that enable early resistance, underscoring the need for molecularly resolved, evolution-aware treatment strategies

MDM2 knockdown mediated by a triazine-modified dendrimer in the treatment of non-small cell lung cancer

Research into sulforaphanes impact on autism spectrum disorder (ASD) reveals a pattern of behavioral improvements during treatment, which tend to regress after the discontinuation of the compound

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In addition, we specify the expected measurement noise assuming a log-normal distribution with constant standard deviation for each measured target