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The prevalence of pruritus varies depending on the underlying cause, with reports indicating rates of up to 70% in primary biliary cholangitis, 2.530% in chronic hepatitis C virus-related liver disease, and roughly 8% in cirrhosis attributed to hepatitis B virus infection ( Numerous hypotheses have been posited to elucidate the genesis of pruritus, albeit none deemed definitive

A neuropsychological test battery, as well as clinical and self-report scales along with general and social functioning were used to assess the degree of depression

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Many find their effective maintenance dose at 5 mg, 7.5 mg, or 10 mg and stay there

Journal of American Heart Association