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The Cochrane Database of Systematic Reviews (4) CD004514

Wang, L.-L

Clinicians can reduce plaque-retentive features at the abutmentimplant complex by selecting smoother surfaces, but they have limited tools to actively increase soft-tissue affinity while simultaneously making the interface less permissive to early colonization

In the context of GLP-1 receptor biology, where chronic high-level receptor activation can lead to tachyphylaxis (reduced responsiveness over time), partial agonism could potentially maintain a more sustained therapeutic effect over extended treatment periods

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