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The skin brightening and lightening properties of Glutathione Therapy are thought to be primarily from stimulation of pheomelanin (lighter) pigment production rather than eumelanin (darker)

Using an ERE-luciferase mouse, a reporter mouse that allows monitoring of ER transcriptional activity in a spatiotemporal manner, it was demonstrated that estrogen signaling is locally activated in keratinocytes in vitro (with 1 nM E2) and in vivo (with 10 nM E2)

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Chidamide (CHI), a histone deacetylase inhibitor, diminished breast cancer growth and metastasis, enhanced ULK2-mediated autophagy, and increased cellular sensitivity to DOX-induced apoptosis, indicating its potential application in combating chemoresistance (145)